Module 01 – The History and Principles of Toxicology

This module serves as a good first introduction to toxicology. In the first part of the module, students will learn and understand: the history of toxicology and its underlying principles; the progression of toxicology as a science; the development of regulatory agencies; key case studies that developed the field; and the paradox of uncertainty. In the second part of the module, students will learn and understand: the general principles of toxicology; how dose determines the effect of a substance; and the factors that affect the toxicity of a chemical. There are multiple case studies throughout these slides.

What’s included?

• Lectures:
  • “1AB – History of Toxicology” (2-3 hours)
  • “1C – Principles of Toxicology” (1-2 hours)
• Lesson Plans:
  • For all lectures
• Supplementary Information:
  • Two student assignments

Keywords: history, principles, timeline, regulation, case studies, dose, dose-response, LD50.

File Size: 30 MB

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Module 02 – Understanding Hazard and Risk

This module is an introduction to understanding the principles of hazard and risk. The lectures are designed with a “choose your own adventure” format: you can take any slides and use them in any order to build your lecture! Using these materials, students will understand the basic concepts of hazard, exposure, and risk; be able to perform a simple chemical hazard assessment; be able to compare similarities and differences of a risk assessment and an alternative assessment; and apply alternative assessment concepts to a product. There are multiple case studies in these slides.

What’s included?

• Lectures:
  • “2ABC – Understanding Hazard and Risk” (3-4 hours)
• Lesson Plans:
  • For all lectures
• Supplementary Information:
  • Five student assignments that correspond to lecture slides
  • A list of additional resources for instructors

Keywords: hazard, exposure, risk, organic chemistry, general chemistry, chemical hazard assessment, alternative assessment.

File Size: 39 MB

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Module 03 – Toxicokinetics and Toxicodynamics

This module is an introduction to toxicokinetics and toxicodynamics. The module is split into five lectures addressing: absorption, distribution, biotransformation, excretion, and toxicodynamics. Using these materials, students will be able to: explain and describe ADME; learn introductory biochemistry, chemistry, and anatomy to explain ADME; and explain and describe toxicodynamics. The lecture slides have multiple in-class discussions and assignments throughout.

What’s included?

• Lectures:
  • “3A – Absorption” (0.5-1 hour)
  • “3B – Distribution” (0.5-1 hour)
  • “3C – Biotransformation” (0.5-1 hour)
  • “3D – Excretion” (0.5-1 hour)
  • “3E – Toxicodynamics” (1-2 hours)
• Lesson Plans:
  • For all lectures
• Supplementary Information:
  • Two student assignments
  • Additional resources for instructors and students

Keywords: ADME, biochemistry, organic chemistry, general chemistry, anatomy, toxicodynamics.

File Size: 29 MB

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Module 04 – Reaction Mechanisms in Toxicology

This module gives an overview of the main reaction mechanisms seen in toxicology studies. Students will learn primarily about the main electrophilic reactions that bind toxicants to proteins, in addition to a brief introduction to reactive oxygen species and radical reactions. This module pairs well with Module 11 – Structure-Activity Relationships, and these lecture slides are also included for your convenience! Finally, the full deck of ChemToxTidbits (one-slide case studies on specific organic chemistry reactions and their relationship to toxicology) are included.

What’s included?

• Lectures:
  • “4AB – Reaction Mechanisms in Toxicology” (1-2 hours)
  • “11A – Structure-Activity Relationships” (1-2 hours)
  • “11B – Structure-Activity Relationships” (1-2 hours)
  • “ChemToxTidbits Slides” (to be used individually)
• Supplementary Information:
  • Two student assignments.

Keywords: electrophilic reactions, organic chemistry, protein binding, structure-activity relationships, general chemistry, reactive oxygen species, antioxidants.

File Size: 19 MB

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Module 06 – Toxicity of Metals

This module is a good introduction to metal toxicity. Students will learn about: toxicity of metals in the body, metal pollution, the difference between metals and metalloids, mechanisms of heavy metal toxicity, and factors that affect metal toxicity. These lecture slides are heavily case-study based and provide an applied outlook on the chemistry with reference to many global incidents and situations. Multiple in-class assignments and student activities can be found within the slides, not in separate documents.

What’s included?

• Lectures:
  • “6ABC – Toxicity of Metals” (3-4 hours)
• Lesson Plans:
  • For all lectures
• Supplementary Information: contained within the lecture slides and lesson plan

Keywords: metals, heavy metals, metal toxicity, metal pollution, essential metals, toxic metals, metalloids, health effects, exposure, general chemistry, inorganic chemistry, environmental chemistry.

File Size: 633 MB – this file is very large, please ensure you have good internet connectivity and time for the download to occur before downloading.

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Module 07 – Environmental Fate, Persistence, and Biodegradation

This module contains an introduction to the concepts of fate, persistence, and biodegradation. Students will learn about: classes of molecules that persist in the environment; different types of degradation and their critical role in the environment and society; and parameters that affect biodegradation rate. Part II of this module is a full case study entirely based on the Deepwater Horizon oil spill. The remaining lecture slides also contain multiple in-class discussions, activities, and smaller case studies.

What’s included?

• Lectures:
  • “7ABC – Environmental Fate, Persistence and Biodegradation” (3-4 hours)
• Lesson Plans:
  • For all lectures
• Supplementary Information:
  • Deepwater Horizon oil spill full case study (1 hour)
  • Materials for students to complete the case study assignment

Keywords: fate, persistence, biodegradation, organic chemistry, general chemistry, environmental chemistry.

File Size: 165 MB – this file is large, please ensure you have good internet connectivity before downloading.

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Module 08 – Environmental Toxicology

This module serves as an introduction to the principles of environmental toxicity: air pollution, water pollution, and chemical transport and fate. Using these materials, students will learn examples of pollutants and their effects on human health and the environment through multiple case studies and in-class discussions. These lecture slides comprise mostly case studies and provide a good outlook on the chemistry through consideration of specific human experiences across the globe. Supplementary information such as activities and discussions are found within the lecture slides, not in separate documents.

What’s included?

• Lectures:
  • “8A – Air Pollution” (1-2 hours)
  • “8B – Water Pollution” (1-2 hours)
  • “8C – Chemical Transport and Fate” (1-2 hours)
• Lesson Plans:
  • For all lectures
• Supplementary Information: contained within the lecture slides and lesson plan

Keywords: pollution, metals, health effects, exposure, general chemistry, inorganic chemistry, environmental chemistry, atmospheric chemistry, water chemistry, aquatic organisms.

File Size: 716 MB – this file is very large, please ensure you have good internet connectivity and time for the download to occur before downloading.

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Module 09 – Ecotoxicology

This module provides: an introduction to ecotoxicology, an overview of exposure and thresholds, an overview of the main concepts and scales of ecotoxicology, and some applications of ecotoxicology. Using these materials, students will learn: the history of ecotoxicology; why ecotoxicology is important to sustainability; effects on levels of biological organization; relations to hazard and risk assessment; relations to broader green chemistry concepts; and analysis and interpretation of ecotoxicology datasets. Multiple case studies and in-class activities are provided in the lecture slides, not in separate documents.

What’s included?

• Lectures:
  • “9A – Intro to Ecotoxicology” (1-2 hours)
  • “9B – Exposure and Thresholds in Ecotoxicology” (1-2 hours)
  • “9C – Concepts and Scales of Ecotoxicology” (1-2 hours)
  • “9D – Applications of Ecotoxicology” (1-2 hours)
• Supplementary Information: contained within the lecture slides and lesson plan

Keywords: ecotoxicology, exposure, hazard, risk, scale, applications, general chemistry, organic chemistry, environmental chemistry.

File Size: 14 MB

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Module 10 – Predictive Toxicology

This module provides an overview of computational methods to predict the toxicity of chemicals. Students will learn an updated overview of the latest methods that have been successfully applied to predict toxic effects of chemicals, in addition to understanding the outlook towards at the nexus of computational sciences and toxicology. Particular emphasis is placed on carbon-based toxicants. Multiple case studies and in-class discussions and assignments are provided in the lecture slides in addition to an extensive set of homework activities for students to do outside of the classroom. You will additionally gain access to multiple GAMESS activities and problem sets.

What’s included?

• Lectures:
  • “10A – Computational Chemistry in Toxicology” (2-3 hours)
  • “10B – Developing Descriptors by Model Size and Detail Level”
• Lesson Plans:
  • For all lectures
• Supplementary Information:
  • GAMESS tutorials
  • Four homework assignments
  • Installation files
  • Past problem sets
• Supplementary Videos: Recordings of these lectures being used in class. Coming soon!

Keywords: computational chemistry, predictive toxicology, organic chemistry, toxicant effects, modelling, datasets, energy levels, general chemistry.

File Size: 881 MB – this file is very large, please ensure you have good internet connectivity and time for the download to occur before downloading.

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Module 11 – Structure-Activity Relationships

This module connects the structure of molecules to their activity in biological systems. Students will be able to: identify physicochemical properties related to ADME; identify and rationalize relationships between physiochemical properties and biological activity in different species; apply pre-screening tools for acute and chronic human and ecological endpoints based on physicochemical properties; and identify potential toxicants. Particular emphasis is placed on carbon-based toxicants and this Module aligns very closely with Module 4 – Reaction Mechanisms in Toxicology and can act as a supporting resource. Multiple in-class assignments and case studies are contained in the lecture slides for students to complete during class lectures.

What’s included?

• Lectures:
  • “11A – Structure, Physicochemical Properties, and Biological Activity” (2-3 hours)
  • “11B – Structure, Physicochemical Properties, and Biological Activity” (2-3 hours)
• Supplementary Information: contained within the lecture slides and lesson plan, in addition to:
  • A glossary of terms
  • Supplemental data on flammability
  • A list of resources for instructors to refer to

Keywords: structure-activity, physicochemical properties, predictive toxicology, organic chemistry, computational chemistry, biological activity, biochemistry.

File Size: 10 MB

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Module 12 – Case Studies, ChemToxTidbits, “Grab Bag” Folder

Don’t have much time to prepare your lectures? Don’t know where to start with incorporating toxicology into existing class lectures or assignments? Not sure if you’re ready to adopt a full module? Do you just want access to the case studies, in-class assignments, homework assignments, and ChemToxTidbits slides? This folder contains all of these materials in a format easily accessible to you, so that you can quickly incorporate small amounts of toxicology and green chemistry into your lectures, labs, and classes as needed.

What’s included?

• Individual case study slides: copy-pasted from lectures in Modules 1-11, designed to be used as standalone exercises in a full lecture
• A list of lectures that mostly comprise case studies and in-class assignments: for future reference
• Example module assignments: Ten homework assignments that can easily be integrated into general chemistry, organic chemistry, environmental chemistry, or inorganic chemistry classes
• ChemToxTidbits slides: one-slide “mini” case studies on specific organic chemistry reactions or toxicants and their relationship to toxicology

File size: 44 MB

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