Module 11 – Structure-Activity Relationships
This module connects the structure of molecules to their activity in biological systems. Students will be able to: identify physicochemical properties related to ADME; identify and rationalize relationships between physiochemical properties and biological activity in different species; apply pre-screening tools for acute and chronic human and ecological endpoints based on physicochemical properties; and identify potential toxicants. Particular emphasis is placed on carbon-based toxicants and this Module aligns very closely with Module 4 – Reaction Mechanisms in Toxicology and can act as a supporting resource. Multiple in-class assignments and case studies are contained in the lecture slides for students to complete during class lectures.
- “11A – Structure, Physicochemical Properties, and Biological Activity” (2-3 hours)
- “11B – Structure, Physicochemical Properties, and Biological Activity” (2-3 hours)
- Supplementary Information: contained within the lecture slides and lesson plan, in addition to:
- A glossary of terms
- Supplemental data on flammability
- A list of resources for instructors to refer to
Keywords: structure-activity, physicochemical properties, predictive toxicology, organic chemistry, computational chemistry, biological activity, biochemistry.
File Size: 10 MB