Lecture 23 – Molecular Toxicology
This lecture introduces Absorption, Distribution, Metabolism, and Excretion (ADME) concepts and how chemists can take advantage of physicochemical parameters like logP, molecular weight, and vapor pressure to redesign molecules that won’t absorb into the body, limit distribution, and facilitate metabolism and excretion. These concepts are reinforced by an in-class exercise that explores potential absorption routes by benzene. The lecture also explores new approaches to hazard minimization through molecular design.
Lesson download includes:
Lesson Plan 23: Molecular Toxicology
Presentation 23: Molecular Toxicology
Content Preview: Absorption, Distribution, Metabolism, and Excretion (ADME), Characteristics of an “ideal chemical”, Approaches to hazard minimization through molecular design
Class Exercise: ADME and Rational Design & Electrophilic Reactions with Answer Keys
Reading for Exercise: Electrophiles in Predictive Toxicology