Beyond Benign

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Electrophilic Reactions

The toxicity of xenobiotic (a substance foreign to the body, typically a chemical substance) electrophiles are related to their ability to bind to proteins in the body. There are about 50 specific reactive protein binding mechanisms known, with 6 being the most common reaction mechanisms: SN1, SN2, Acylation, Schiff Base formation, Michael Addition and SNAr. This unit provides a brief introduction to electrophilic-nucleophilic reactions in the body, along with some discussion questions for instructors.

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Electrophilic_Reactions.docx